There are no agent settings that enable it to be bound to a specific network interface. By interface By default the up.time agent , the Uptime Infrastructure Monitor Agent is designed to listen to all interfaces on port 9998.
It is possible to provide alternate options in some cases. For example, if you are using the up.time Linux agent the Uptime Infrastructure Monitor Linux Agent and running via xinetd, you can edit the agent xinetd script (/etc/xinetd.d/uptmagnt) to bind to a specific interface. Refer to Access Control Using xinetd on the Centos website for more information.