No. Although the default up.time default Uptime Infrastructure Monitor configuration includes a bundled MySQL database, the up.time the Uptime Infrastructure Monitor database connection is designed to allow the DB to reside on a different server. The remote database may run on an Oracle or SQL Server.
Please view Supported Databases in up.timeUptime Infrastructure Monitor to see a list of supported database versions.
Please refer to Migrating Your DataStore To a New Database.