No. Although the default up.time configuration includes a bundled MySQL database, the up.time database connection is designed to allow the DB to reside on a different server. The remote database may run an Oracle , or SQL Server or MySQL DataStore.
Please view Supported Databases in up.time to see a list of supported database versions.
Please refer to Migrating Your DataStore To a New Database and Moving your MySQL DataStore to a Remote Host for information on migrating your default bundled MySQL database.